承担 的主 要项 目及 成果 |
承担的主要项目: · 陕西科技大学科研启动金:用于蛋白质动态学研究的刚性顺磁探针的构建,2020.07-2023.07,主持。 · 陕西省自然科学基础研究计划项目(2021JQ-532):蛋白质超顺磁性探针的设计与合成-用于蛋白质动态学研究,2021.01.2022.12,主持。 · 国家自然科学基金委青年基金项目(22107060):用于细胞内蛋白质结构研究的荧光活性顺磁性探针,2022.01-2024.12,主持。 主要科研成果: 1. Qing Miao, Wei-Min Liu, Thomas Kock, Anneloes Blok, Monika Timmer, Mark Overhand, Marcellus Ubbink*. A double armed, hydrophilic, transition metal complex as paramagnetic NMR probe. Angew. Chem. Int. Ed, 2019, 58, 13093–13100. 2. Qing Miao#, Enrico Zurlo#, Simon Peter Skinner, Donny de Bruin, Joeri Wondergem, Anneloes Blok, Monika Timmer, Mark Overhand, Martina Huber*, Marcellus Ubbink*. A two-armed probe for in-cell DEER measurements on proteins. Chem. Eur. J. 2020, 26 (71), 17128–17133. 3. Qing Miao, Christoph Nitsche, Mark Overhand, Gottfried Otting, Marcellus Ubbink, Protein paramagnetic NMR probes: synthesis and applications, Chem. Rev. (accepted) 4. Qing Miao, Mark Overhand, and Marcellus Ubbink. Rigidified and hydrophilic DOTA-like lanthanoid ligands: Design, synthesis, NMR studies and molecular modelling. (To be submitted) 5. Qing Miao, Xiangli Chen, Lingling Liu, Yu Fang*. Synergetic effect based gel-emulsions and their utilization for the template preparation of porous polymeric monoliths, Langmuir, 2014, 30, 13680−13688. 6. Xuwei Fu, Pei Wang, Qing Miao, Kaiqiang Liu, Huijing Liu, Jianfei Liu and Yu Fang*. Polymerizable organo-gelator-stabilized gel-emulsions toward the preparation of compressible porous polymeric monoliths. J. Mater. Chem. A, 2016, 4, 15215–15223. 7. Xiangli Chen, Lingling Liu, Kaiqiang Liu, Qing Miao, Yanchao Lv and Yu Fang*, Compressible porous hybrid monoliths: preparation via a low molecular mass gelators-based gel-emulsion approach and exceptional performances, J. Mater. Chem. A, 2015, 3, 24322-24332. 8. Xiangli Chen, Lingling Liu, Kaiqiang Liu, Qing Miao and Yu Fang*. Facile preparation of porous polymeric composite monoliths with superior performances in oil–water separation-a low-molecular mass gelators-based gel emulsion approach, J. Mater. Chem. A, 2014, 2, 10081-10089. 9. 薛敏,苗青,房喻*, 基于胆固醇的新型小分子胶凝剂的合成与胶凝行为, 物理化学学报, 2013, 29, 2005-2012. |